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Scientific Studies and Reviews
Important note: The overwhelming majority of studies are conducted with spirulina, meaning that the phycocyanin present in spirulina is found in much smaller quantities than in the E40 form as in phyco+, and furthermore, it will only be released with spirulina in the intestine, which means it has very little effect on the body compared to taking it in pure E40 form as with Phyco+
SOURCE: https://pmc.ncbi.nlm.nih.gov/articles/PMC10144176
https://lifes-code.com/what-is-phycocyanin-benefits-absorption-use/
Oxygenation: Phycocyanin can increase hemoglobin and improve blood oxygenation, which helps the body transport and use oxygen more efficiently, leading to more strength, endurance, greater mental clarity, and numerous benefits. The studies conducted are at minimum doses and still show results; ANKA's Phyco+ contains much higher doses of phycocyanin, and therefore has more effect while remaining within safe doses.
https://pubmed.ncbi.nlm.nih.gov/37807529/
https://pubmed.ncbi.nlm.nih.gov/21880207/
Anti-fatigue and mental clarity: In a randomized, double-blind, placebo-controlled trial, men took 3 g/day of spirulina. As early as 4 hours after the first dose, a statistically significant improvement in performance on a mental fatigue test was observed. These positive effects persisted for up to 8 weeks of supplementation. Participants also reported better perception of their mental and physical fatigue.
https://pubmed.ncbi.nlm.nih.gov/26888417/ (at 3g of spirulina per day, as a reminder, phycocyanin in spirulina is less well absorbed and is present in much smaller quantities than in Phyco+)
Against Cancer: There is human evidence (controlled clinical, patent reported cases) that phycocyanin is used as support during anticancer treatments, particularly to strengthen the immune response and against chemotherapy-induced neuropathy. Experimental data (in vitro/in vivo) show that PC has a direct anti-tumor potential, especially in combination with other drugs.
https://pubmed.ncbi.nlm.nih.gov/36670495/
https://pubmed.ncbi.nlm.nih.gov/35116849/
Immunity: Phycocyanin has demonstrated immunomodulatory activity in humans: in a clinical study, supplementation significantly increased the number of T lymphocytes and IgM antibody production, thereby improving the immune response without notable side effects PubMed PMID: 35116849.
Others: Phycocyanin, a pigment-protein extracted from Spirulina, protects cells against oxidative stress by neutralizing free radicals, limits intracellular inflammation, and promotes cell survival, thus contributing to maintaining the health and function of cells in various tissues https://pubmed.ncbi.nlm.nih.gov/35112789/
Effect of combinations
Phycocyanin + Vitamin C
Helps protect cells against oxidative stress, with vitamin C regenerating phycocyanin after oxidation and enhancing its antioxidant activity.
Phycocyanin + Ginger
Contributes to joint well-being and digestive comfort, with ginger compounds acting synergistically with phycocyanin to support cellular health and reduce oxidative stress.
Phycocyanin + Astaxanthin
Participates in protecting cells against oxidative stress, with phycocyanin acting in aqueous environments and astaxanthin in lipid environments for complementary antioxidant coverage.
Phycocyanin + Piperine (black pepper)
Promotes the bioavailability of certain fat-soluble nutrients like astaxanthin or ginger, indirectly improving the overall effectiveness of the combination with phycocyanin.