TESTOFULL

Pycnogenol (maritime pine bark extract, 60 mg) indirectly supports testosterone by improving blood circulation and endothelial health, reducing oxidative stress and inflammation, which promotes better functioning of the hypothalamic-pituitary-gonadal axis.

https://esmed.org/MRA/mra/article/view/1865? (+18.9% testosterone in 4 weeks in men aged 30 to 50)

https://pubmed.ncbi.nlm.nih.gov/21618639/

Nettle root (Urtica dioica) extract can support testosterone by releasing bound testosterone from SHBG (thanks to lignans), by reducing aromatase (thus conversion to estrogens) and by exerting anti-inflammatory and prostate-protective effects, which promotes a better androgenic balance.

https://pubmed.ncbi.nlm.nih.gov/7700987/

https://www.sciencedirect.com/science/article/abs/pii/S0944711307000542

Zinc bisglycinate (5 mg) can support testosterone by participating in hormone synthesis, reducing inflammation, limiting excess cortisol, supporting testicular and sperm health, and maintaining an optimal balance of the hypothalamic-pituitary-gonadal axis.

https://pubmed.ncbi.nlm.nih.gov/8875519/

Boron bisglycinate (1.5 mg) can support testosterone by reducing SHBG (a protein that inactivates testosterone), improving estrogen metabolism, decreasing cortisol, and promoting an overall hormonal balance that stimulates testosterone production and availability.

https://pmc.ncbi.nlm.nih.gov/articles/PMC4712861/

Spermidine (1.2 mg, wheat germ extract) can support testosterone by stimulating cellular autophagy, reducing oxidative stress and inflammation, improving mitochondrial health, and promoting testicular function and hormone production via a healthier cellular environment.

https://www.scirp.org/journal/paperinformation?paperid=90920

Cordyceps militaris supports testosterone indirectly by improving cellular energy, blood circulation, libido, mitochondrial function, reducing oxidative stress, and immune balance.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5236007/

https://www.nature.com/articles/s41598-024-58742-z

https://pmc.ncbi.nlm.nih.gov/articles/PMC4791983

L-Tyrosine supports testosterone by promoting dopamine production, which stimulates LH (luteinizing hormone) release, while limiting the negative effect of stress and cortisol on the hormonal axis.

https://pubmed.ncbi.nlm.nih.gov/8293316/

https://pubmed.ncbi.nlm.nih.gov/8293316/

https://www.ncbi.nlm.nih.gov/books/NBK209061/

https://pubmed.ncbi.nlm.nih.gov/2736402/

Zinc Bisglycinate + Boron Bisglycinate → This is the strongest combination for increasing free testosterone and reducing estradiol. Zinc supports testosterone synthesis and testicular health, while boron promotes conversion to free testosterone and improves FT/E2 and FT/T ratios.

L-Tyrosine + Boron/Zinc → Tyrosine stimulates dopamine, which can increase LH and support the hypothalamic-pituitary-gonadal axis, thereby potentiating the effects of zinc and boron on testosterone.

Cordyceps militaris + Pycnogenol → Act indirectly by improving blood circulation, mitochondrial function, and reducing oxidative stress, creating a more favorable environment for hormone production.

Spermidine → Supports testicular health and hormone production via autophagy and mitochondrial function, but direct human evidence on testosterone is limited.